Oleg Bol’shakov Curriculum Vitae 05.12.2013
OLEG BOL’SHAKOV, Ph. D.
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Center of Excellence
School of Pharmacy at
Howard University,
2300 4th st. NW,
Washington DC, 20059, USA
Tel.: (202) 806-4154
Cell: (352) 328-2386
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I.CAREER GOAL
Position for interdisciplinary research accompanied with organic synthesis.
II. EDUCATION AND QUALIFICATION
2009 Candidate of Sciences in Organic Chemistry
2006 Master Degree in Organic Chemistry
2001-2006 Chelyabinsk State University, Department of Chemistry
III. PROFESSIONAL APPOINTMENTS:
01.2012 – until now Research associate in Emmanuel Akala research group at
School of Pharmacy, Howard University
01.2010 – 01.2012 Adjunct Associate Chemistry in Katrtitzky
Research Group, University of Florida
10.2009-01.2010 Research engineer P&M-invest,
28, Vavilova str., Moscow, 119991, Russia
2006-2009 Junior Research Associate, N.D. Zelinsky Institute for
Organic Chemistry, RAS, Moscow
Oleg Bol’shakov Curriculum Vitae 05.12.2013
IV. RESEARCH INTEREST AND SPECIALTIES:
Chemistry of Heterocyclic Compounds
Sulfur-Nitrogen and Polysulfur Heterocycles
Fluorine Chemistry
Functionalized aminoacids. Peptide synthesis (incl. SPPS) and modification.
Nanoparticle synthesis. Surface modification of nanoparticles.
My 7-year synthetic experience at Industrial and Academic research areas provides versatile
tools for non-trivial challenges either for independent or collaborative studies.
V. TECHNICAL SKILLS
Profound experience in multi-step organic synthesis. Qualified in optimization of reaction
conditions and scale up of processes. Competent in purification techniques as well as in
analytical methods, most of which are done by self: TLC, NMR (Both 1H and 13C), IR, UV,
HPLC (Analytical and Preparative), MS: MALDI, ESI). Skilled in use of Chemistry Related
software: ChemDraw, ACD Labs, MestRenova, XCalibur. Well versed with Cross-Fire
(Beilstein) and SciFinder databases. Language skills: native Russian, fluent English.
VI. PUBLICATIONS
Total number of publications - 15, including papers and abstracts.
SCIENTIFIC PUBLICATIONS
1. L. S. Konstantinova, O. I. Bol’shakov, N. V. Obruchnikova, H. Laborie, A. Tonga, V.
Sopéna, I. Lanneluc, L. Picot, S. Sablé, V. Thiéry, O. A. Rakitin “One-pot synthesis of 5-
phenylimino, 5-thione and 5-one-1,2,3-dithiazoles and evaluation of their antimicrobial and
antitumor activity” Bioorg. Med. Chem. Lett., 2009, 19(1), 136-141.
Oleg Bol’shakov Curriculum Vitae 05.12.2013
2. L. S. Konstantinova, O. I. Bol’shakov, N. V. Obruchnikova, S. P. Golova, Y. V. Nelyubina,
K. A. Lyssenko, O. A. Rakitin “Reactions of 4-substituted -5H-1,2,3-dithiazole-5-thiones and 5-
ones with primary amines: novel synthesis of 1,2,5-thiadiazole-3(2H)-thiones and –ones”
Mendeleev Commun., 2009, 2, 84-86.
3. V. V. Popov, О. I. Bolshakov, L. S. Кonstantinova, О. А. Rakitin “One-pot synthesis and
chemistry of 4-substituted-5Н-1,2,3-dithiazole-5-ylidenes” Izv. Akad. Nauk, Ser. Khim., 2009,
# 2, 429-432.
4. Lidia S. Konstantinova, Oleg I. Bol'shakov, Natalia V. Obruchnikova, Svetlana P. Golova,
Yulia V. Nelyubina, Konstantin A. Lyssenko, Oleg A. Rakitin “Reactions of 4-substituted 5H-
1,2,3-dithiazoles with primary and secondary amines: fast and convenient synthesis of 1,2,5-
thiadiazoles, 2-iminothioacetamides and 2-oxoacetamides” Tetrahedron., 2010, 66, 4330–4338.
5. Oleg I. Bol'shakov, Lidia S. Konstantinova, Rinat Aysin, Natalia V. Obruchnikova, Elena D.
Lubuzh and Oleg A. Rakitin “Unexpected formation of 5,5-diethoxy-5H-1,2,3-dithiazoles from
5H-1,2,3-dithiazole-5-thiones” Mendeleev Commun., 2010, 20, 212-214.
6. Katritzky, A. R.; El Khatib, M.; Bol’shakov, O.; Khelashvili, L.; Steel, P. J. “Benzotriazol-1-
yl-sulfonyl Azide for Diazotransfer and Preparation of Azidoacylbenzotriazoles” J. Org. Chem.
2010, 75, 6532-6539.
7. El Khatib M., Elagawany M., Jabeen F., Todadze E., Bol’shakov O., Oliferenko A.,
Khelashvili L., El-Feky S., Asirie A. and Katritzky A. “Traceless chemical ligations from Oacyl
serine sites” - Org. Biomol. Chem., 2012, 10, 4836.
8. Bol'shakov, O.; Lebedyeva, I.; Katritzky, A. “17-ethynylestradiol peptide labeling by
"click" chemistry” - Synthesis 2012, 44(18), 2926-2932
9. Bol’shakov O., Kovacs J., Chahar M., Khelashvili L. and Katritzky, A. R , S- to N-Acyl
transfer in S-acylcysteine isopeptides via 9-, 10-, 12-, and 13-membered cyclic transition states
– J. Pept. Sci. 2012, 18(11) 704–709.
ABSTRACTS AND PRESENTATIONS
1. L. S. Konstantinova, О. I. Bol’shakov, N. V. Оbruchnikiova, О. А. Rakitin “ One-pot
synthesis of 4-substituted 5H-1,2,3-dithiazoles” Abstracts of X Russian Conference of Organic
Chemistry Among Young Scientists, November 26-30, 2007, Ufa.
Oleg Bol’shakov Curriculum Vitae 05.12.2013
2. L. S. Konstantinova, O. I. Bol’shakov, O. A. Rakitin “Bi-1,2,3-dithiazoles and their
rearrangement to isothiazolo[5,4-d]isothiazoles” Abstracts of the 23nd International Symposium
on the Organic Chemistry of Sulfur, Moscow, Russia, 2008, June 29 – July 4, P 93.
4. О. I. Bol’shakov, L. S. Кonstantinova, Rakitin О. А. “One-pot synthesis of 4-substituted 5H-
1,2,3-dithiazoles and their chemistry” Abstracts of III Conference Among Young Scientists IOC
RAS, April 23 – 24, 2009, Moscow, p. 10-12.
5. L. S. Konstantinova, O. I. Bol’shakov, N. V. Obruchnikova, O. A. Rakitin, H. Laborie, A.
Tonga, V. Sopéna, I. Lanneluc, S. Sablé, V. Thiéry “One-pot synthesis of 5-phenylimino, 5-
thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial activity” Abstracts of the
10th Annual Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference, Florida, USA,
2009, March 8 – 11, p. 75.
6. L. S. Konstantinova, О. I. Bol’shakov, N. V. Оbruchnikova, S. P. Golova, О. А. Rakitin
«Reaction of recyclisation of 4-substituted 5H-1,2,3-dithiazole -5-ones and 5-thiones with
primary amines treatment» Abstracts of I International conference "New Routes in Chemistry
of Heterocyclic Compounds" May 3-8, 2009 , Kislovodsk, р. 349.
7. Oleg Bol’shakov, Mirna El Khatib, Levan Khelashvili “Reaction of N-(a-
Azidoacyl)benzotriazoles with C-, N-, O- and S- Nucleophiles” Abstracts of the 11th Annual
Florida Heterocyclic and Synthetic IUPAC-Sponsored Conference, Florida, USA, 2011, March
6 – 9, p. 125.
